WOUND MANAGEMENT

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MatriStem UBM™ Products

Cytal® Burn Matrix Devices

Cytal Burn Matrix is a medical device engineered using ACell’s proprietary MatriStem UBM™ (Urinary Bladder Matrix) technology.

The device maintains an intact epithelial basement membrane and facilitates the body’s ability to remodel site-appropriate functional tissue1. Cytal Burn Matrix is appropriate for the management of severe second degree burns.

Provides a scaffold for natural remodeling
Contains an intact epithelial basement membrane and numerous collagens
Rapid coverage of burn injury
Complements standard of care

Cytal Burn Matrix

BMM05055 x 5 cm1/box

BMM07107 x 10 cm1/box

BMM101510 x 15 cm1/box

Second Degree Burns

Second degree burns affect the epidermis and dermis layers of the skin. Current approaches for the management of burns, such as skin grafting, can often result in scarring and contracture which can impair tissue functionality. Cytal Burn Matrix devices are designed for deep secondary degree burn management and have been shown to facilitate the body’s ability to remodel site appropriate, biomechanically functional tissue where scarring would be expected. The devices can facilitate ingrowth of vascularized tissue to support skin graft take18-19. The product can also be used to manage wounds to full closure without the need for autologous skin grafting.

Cytal® Wound Matrix Devices

ACell’s wound management products are medical devices that maintain and support a healing environment by facilitating remodeling of site-appropriate, functional tissue1.

Comprised of naturally-occurring urinary bladder matrix (UBM), these products maintain an intact epithelial basement membrane. Cytal devices are appropriate for acute wounds and chronic wounds.

Non-crosslinked wound management scaffold
Provides a scaffold for cellular infiltration1 and neovascularization
Results in site-appropriate tissue where scarring would be expected
Pre-fenestrated to support effective fluid management and wound drainage
Complements standard of care

1. Cytal Wound Matrix 1-Layer

WS03033 x 3.5 cm1/box

WS03073 x 7 cm1/box

WS07107 x 10 cm1/box

WS101510 x 15 cm1/box

2. Cytal Wound Matrix 2-Layer

WSM05055 x 5 cm1/box

WSM07107 x 10 cm1/box

WSM101510 x 15 cm1/box

3. Cytal Wound Matrix 3-Layer

WSR05055 x 5 cm1/box

WSR07107 x 10 cm1/box

WSR101510 x 15 cm1/box

4. Cytal Wound Matrix 6-Layer

WSX05055 x 5 cm1/box

WSX07107 x 10 cm1/box

WSX101510 x 15 cm1/box

Traumatic Wounds

MicroMatrix and Cytal Wound Matrix are available in various configurations to offer surgeons more options when managing traumatic injuries. The products are easy to use, and are highly conformable in irregular and large wounds.

Traumatic injuries often have significant soft tissue loss. Cytal Wound Matrix and MicroMatrix have successfully been used for traumatic wounds that are unable to obtain flap or graft coverage26. The products have also been used to facilitate the remodeling of site-appropriate, functional tissue1 and manage wounds to full closure without the use of autologous skin grafts

Necrotizing Soft Tissue Infections

Necrotizing soft tissue infections (NSTIs) occur when certain types of bacteria, viruses, or fungus get into a patient’s tissues, typically via a break in the skin. Once these microorganisms get into the tissues they reproduce, releasing a toxin into the body that destroys the surrounding tissue and muscle. NSTIs are associated with high mortality rates and require prompt treatment, which typically includes aggressive surgical removal of the diseased tissue.

Many survivors experience dramatic tissue loss and/or amputations that may require major reconstructive and cosmetic surgery. MicroMatrix and Cytal Wound Matrix can facilitate the remodeling of functional tissue1 and relieve some of the complexities of typical reconstruction procedures after major soft tissue loss

Diabetic Foot Ulcers

Diabetic foot ulcers (DFUs) are common, but when they fail to heal and become chronic, they impair the quality of life of the patient, and can lead to severe complications. ACell’s UBM technology has been shown to modulate the immune response in wounds of diabetic patients. MicroMatrix and Cytal Wound Matrix may assist in diabetic wound healing by restoring an inflammatory state similar to that of non-diabetic patients27. ACell devices have also been shown to be a cost-effective alternative for the treatment of DFUs compared to other ECM

Gentrix® Surgical Matrix Devices

Gentrix Surgical Matrix products are medical devices engineered using ACell’s proprietary MatriStem UBM™ (Urinary Bladder Matrix) technology and are intended to reinforce soft tissue where weakness exists.

The Gentrix extracellular matrix scaffold has been shown to facilitate the body’s ability to remodel site-appropriate functional tissue1 where scarring would be expected. Gentrix Surgical devices are appropriate for a range of surgical procedures including various types of hernia repair.

Contains an intact epithelial basement membrane and numerous collagens
Non-crosslinked scaffolds that allow for the repair and remodeling of damaged tissues
Available in a variety of configurations
Offers ease in handling and securing
May minimize the risk of costly complications such as foreign body response, erosion, and infection, which are often associated with synthetic products

1-Gentrix Surgical Matrix Thin

PSM05055 x 5 cm1/box

PSM04124 x 12 cm1/box

PSM07107 x 10 cm1/box

PSM06156 x 15 cm1/box

PSM07157 x 15 cm1/box

PSM101510 x 15 cm1/box

2-Gentrix Surgical Matrix

PSMX05055 x 5 cm1/box

PSMX07107 x 10 cm1/box

PSMX101510 x 15 cm1/box

3.Gentrix Surgical Matrix Plus

MSPL05075 x 7 cm1/box

MSPL07107 x 10 cm1/box

MSPL101010 x 10 cm1/box

MSPL101510 x 15 cm1/box

4.Gentrix Surgical Matrix Thick

PSMT102010 x 20 cm1/box

PSMT162016 x 20 cm1/box

PSMT202020 x 20 cm1/box

PSMT202520 x 25 cm1/box

PSMT203020 x 30 cm1/box

PSMT303030 x 30 cm1/box

PSMT304030 x 40 cm1/box

5.Gentrix Hiatal

HIAT07066 x 7.5 cm1/box

Ventral Hernias

Gentrix Surgical Matrix devices can be utilized in a variety of complex hernia repairs.

In pre-clinical models of ventral hernia repair, the devices have been shown to fully remodel into tissue that offers the optimal strength needed for repair20, 1
Because the product fully resorbs, it can minimize the risk of costly complications such as foreign body response, erosion, and infection that can occur with synthetic alternatives3-7
In addition, a recent retrospective study demonstrated patient outcomes in complicated hernia rates with only 4% recurrence rate at 24 months (based on Kaplan-Meier Freedom from Recurrence analysis) and 15.6% at 36 months

Hiatal Hernias

Several Gentrix Surgical Matrix products can be used for hiatal hernia repair. The devices remodel into the host tissue, minimizing the risk of erosion or complication. It maintain the integrity of the hiatal hernia repair by facilitating the formation of biomechanically functional tissue.

Comes in a pre-cut “U-Shaped” design
Is designed to be easily handled and secured in laparoscopic surgery
Minimizes attachments from surrounding viscera

MicroMatrix®

ACell’s wound management products are medical devices that maintain and support a healing environment by facilitating remodeling of site-appropriate, functional tissue1.

Comprised of naturally-occurring urinary bladder matrix (UBM). MicroMatrix is appropriate for acute wounds and chronic wounds.

Used concomitantly with Cytal Wound Matrix devices
Offers thorough contact with the wound bed
Ideal for irregular wound beds
Easy to use and apply

MicroMatrix

MM0020 20mg MicroMatrix Micronized Particles1/box

MM0030 30mg MicroMatrix Micronized Particles1/box

MM0060 60mg MicroMatrix Micronized Particles1/box

MM0100 100mg MicroMatrix Micronized Particles1/box

MM0100F 00mg MicroMatrix Micronized Particles (fine)1/box

MM0200 200mg MicroMatrix Micronized Particles1/box

MM0500 500mg MicroMatrix Micronized Particles1/box

MM1000 1000mg MicroMatrix Micronized Particles1/box